fbpx

To Learn More - Click Here to Book a Discovery Call

Reduce Autoimmunity

With: Dr. Alessio Fasano

About the Episode

Understand the relationship between the microbiome and autoimmune disease!

Join Dr. Alessio Fasano, the director of the Center for Celiac Research and Treatment at Mass General for Children in Boston, as he explores the root causes of increasing autoimmune diseases. He shares his years of experience in the field of Celiac Disease and offers insights into reducing your exposure to triggers.

Listen to start feeling better now!

What We Discuss

In the past few decades, there’s been a surge in non-infective inflammatory diseases. The speed of this increase puts the theory of genetic and environmental triggers in jeopardy because three decades of mutation can’t explain the current acceleration of disease rates. For example, the occurrence of Celiac Disease is four times what it was in World War II and only in the Western hemisphere.

One possible cause is Zonulins, a family of proteins that create complex structures between cells. They open gateways between the inside and outside of the cells at tight junctions. This “on” and “off” function is controlled by genes. The loss of barrier function means the cell’s protection is also lost, and substances that should stay mostly outside of a cell can now come in, which can result in chronic inflammation or health issues such as Celiac Disease.

Triggers for Disease

Genetics, environment, and barrier breakdown are all interconnected, and the gut microbiome influences which genes are turned on and off. So if we can figure out what’s triggering these increasing rates in the Western hemisphere, we can slow down or even reverse the occurrence of diseases like Celiac.

Some influencing factors in the West could include having more C-section deliveries, consuming junk food, and being more likely to survive an infection due to antibiotics. The life expectancy of our ancestors was also historically lesser than it is now, meaning there was much less time to develop autoimmunity. This also reduced the amount of time available for the body to develop chronic inflammation or complications from it.

Diets in the West

In parts of Europe and the East, diets are relatively cleaner with more fruits and vegetables, whereas in the West, junk food diets are prevalent. However, it’s not just the fact that having low-quality nutrition causes issues, but also how much and how often. For example, red meat is a known inflammatory food, and Western diets that contain a lot of red meat are likely to increase the rate of inflammation and illnesses caused by it.

There’s also no such thing as a normal, “healthy” microbiome. It’s different for everyone and constantly changing. What’s important is to understand the symbiotic relationship between your body and the bacteria in the gut.

Start taking care of your gut to prevent autoimmune disease triggers with this episode!

Guest Bio

Dr. Alessio Fasano is director of the Center for Celiac Research and Treatment at Mass General for Children in Boston, Massachusetts. He is author of Gluten Freedom, a book for general readers about celiac disease and gluten-related disorders, and co-author with Susie Flaherty of Gut Feelings: The Microbiome and Our Health, published in March 2021 by MIT Press.

Links

Social Media:

https://twitter.com/celiacresearch
https://www.facebook.com/celiacresearch/
https://twitter.com/mghfc
https://www.facebook.com/mghfc/
https://twitter.com/harvardmed
https://www.instagram.com/harvardmed/
https://www.facebook.com/HarvardMed/

Links:
https://www.Celiaccenter.org
https://hms.harvard.edu/departments/hms-celiac-research-program

Book: Gluten Freedom
https://www.amazon.com/Gluten-Freedom-Essential-Gluten-Free-Lifestyle/dp/1681620510

Book: Gut Feelings
https://mitpress.mit.edu/books/gut-feelings

Our Providers

Quick Links

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Ut elit tellus, luctus nec ullamcorper mattis, pulvinar dapibus leo.

WHY DO WE DO THIS TEST?

This test looks for the inappropriate presence of bacteria in the small intestine known as Small Intestinal Bacterial Overgrowth or “SIBO”.

LOCATION PERFORMED

At home

BLOOD FLUID

Breath

COST

*$109 with insurance, $179 without insurance *This test has an initial fee of $109, if your insurance doesn’t cover the test you’ll be charged the extra $70.

WHY DO WE DO THIS TEST?

This test evaluates the presence of harmful mycotoxins (toxins produced by molds).

LOCATION PERFORMED

In office

BLOOD FLUID

Blood

SPECIAL INSTRUCTIONS

Glutathione for 1 week, then bath or sauna.

COST

$99 – $184

INSURANCE

Fully covered by Medicare. Repeat test prices $400.

WHY DO WE DO THIS TEST?

This test evaluates the genetic profile for multiple health indicators.

LOCATION PERFORMED

In office

BLOOD FLUID

Blood

COST

$319

INSURANCE

No insurance accepted

WHY DO WE DO THIS TEST?

This company can test for lyme, babesia, bartonella and additional tick-borne illnesses.

LOCATION PERFORMED

In office

BLOOD FLUID

Blood

COST

$450-$3000

INSURANCE

Fully covered by Medicare. May be reimbursed with PPO plans.

WHY DO WE DO THIS TEST?

This test evaluates the presence of harmful mycotoxins (toxins produced by molds).

LOCATION PERFORMED

At home

BLOOD FLUID

Urine

SPECIAL INSTRUCTIONS

Glutathione for 1 week, then bath or sauna.

COST

$299

INSURANCE

No insurance accepted

WHY DO WE DO THIS TEST?

This test evaluates a wide range of environmental toxins that may be leading to harmful health effects.

LOCATION PERFORMED

At home

BLOOD FLUID

Urine

SPECIAL INSTRUCTIONS

Glutathione for 1 week, then bath or sauna.

COST

$199

INSURANCE

No insurance accepted $30 discount given if done with mycotoxins.

WHY DO WE DO THIS TEST?

This test is designed to look at food sensitivities (IgG immune responses). It is available in both a 99 or 184 panel.

LOCATION PERFORMED

In office

BLOOD FLUID

Blood

NOTES

You often have to fast for these tests.

COST

Depending on the test, deductible or copay may apply.

INSURANCE

Depends on insurance coverage, deductible or copay may apply.

WHY DO WE DO THIS TEST?

Glyphosate (“Round Up”) is a pesticide that is widely used and this test indicates the body’s levels.

LOCATION PERFORMED

At home

BLOOD FLUID

Urine

SPECIAL INSTRUCTIONS

Glutathione for 1 week, then bath or sauna.

COST

$99 ($69 if performed with mycotoxins or environmental toxins).

INSURANCE

No insurance accepted $30 discount given if done with mycotoxins or GPL Tox.

WHY DO WE DO THIS TEST?

This test evaluates many measures including micronutrients, antioxidants, minerals, detox, overview of gut function, omegas and toxic exposure.

LOCATION PERFORMED

In office

BLOOD FLUID

Urine & Blood

COST

$179 – $400

INSURANCE

Depending on insurance coverage. Fully covered by Medicare.

INSTRUCTIONS

WHY DO WE DO THIS TEST?

This test evaluates the gut function and indicates microbiome balance, overgrowth, infection, inflammation, parasites and digestive efficacy.

LOCATION PERFORMED

At home

BLOOD FLUID

Stool

COST

$160-$329

INSURANCE

Depending on insurance coverage. Fully covered by Medicare.

SPECIAL INSTRUCTIONS

No probiotics for one week.

VIDEO INSTRUCTIONS

WHY DO WE DO THIS TEST?

This test evaluates the full menstrual cycle, female hormones, and adrenal profile.

LOCATION PERFORMED

At home

BLOOD FLUID

Urine

COST

$160-$329

INSURANCE

Depending on insurance coverage. Fully covered by Medicare.

NOTES

Must be off hormones in order to do the testing.

WHY DO WE DO THIS TEST?

This test is specifically for a tick-borne illness called “Bartonella”.

LOCATION PERFORMED

In office

BLOOD FLUID

Blood

COST

$260

INSURANCE

No insurance accepted

WHY DO WE DO THIS TEST?

This test evaluates the presence of potentially harmful heavy metals stored in the body.

LOCATION PERFORMED

At home

BLOOD FLUID

Urine

COST

Testing: $138
DMSA: $36

INSURANCE

Not covered by Insurance

WHY DO WE DO THIS TEST?

This test measures saliva cortisol testing throughout the course of one day and informs us where there might be an adrenal imbalance.

LOCATION PERFORMED

At home

BLOOD FLUID

Saliva

COST

$80

INSURANCE

Only covered by Medicare

WHY DO WE DO THIS TEST?

This test is designed to look at food sensitivities (IgG immune responses). It is available in both a 99 or 184 panel.

LOCATION PERFORMED

In office

BLOOD FLUID

Blood

COST

$99 – $184

INSURANCE

No insurance accepted